FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term hydrolase activity, acting on ester bonds ID (Ontology) GO:0016788 (Gene Ontology)
Definition Catalysis of the hydrolysis of any ester bond.
Also Known As "esterase activity"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      35
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 hydrolase activity, acting on ester bonds (all annotations which use CV term, excluding "NOT" statements)       2     35
     enables | hydrolase activity, acting on ester bonds       --      35
Spanning Tree (Parents/Children)
Only view relationship: 
  catalytic activity
   |__hydrolase activity
       |__hydrolase activity, acting on ester bonds  531 rec.
           |__carboxylic ester hydrolase activity 148 rec.
           |   |__1,4-lactonase activity
           |   |__1-alkyl-2-acetylglycerophosphocholine esterase activity
           |   |__2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity
           |   |__2-pyrone-4,6-dicarboxylate lactonase activity
           |   |__3-oxoadipate enol-lactonase activity
           |   |__4-methyloxaloacetate esterase activity
           |   |__4-O-methyl-glucuronoyl methylesterase activity
           |   |__4-pyridoxolactonase activity
           |   |__4-sulfomuconolactone hydrolase activity
           |   |__5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity
           |   |__6-acetylglucose deacetylase activity
           |   |__6-phosphogluconolactonase activity 1 rec.
           |   |__11-cis-retinyl-palmitate hydrolase activity
           |   |__A1-type glycerophospholipase activity(+) 9 rec.
           |   |__A2-type glycerophospholipase activity 13 rec.
           |   |__acetoxybutynylbithiophene deacetylase activity
           |   |__acetylajmaline esterase activity
           |   |__acetylalkylglycerol acetylhydrolase activity
           |   |__acetylsalicylate deacetylase activity
           |   |__acetylxylan esterase activity
           |   |__aclacinomycin T methylesterase activity
           |   |__actinomycin lactonase activity
           |   |__acylcarnitine hydrolase activity
           |   |__acyloxyacyl hydrolase activity
           |   |__all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
           |   |__alpha-amino-acid esterase activity 1 rec.
           |   |__aminoacyl-tRNA deacylase activity(+) 13 rec.
           |   |__arylesterase activity 3 rec.
           |   |__B-type glycerophospholipase activity 1 rec.
           |   |__bis(2-ethylhexyl)phthalate esterase activity
           |   |__brefeldin A esterase activity
           |   |__carboxylesterase activity 26 rec.
           |   |__carboxymethylenebutenolidase activity
           |   |__cephalosporin-C deacetylase activity
           |   |__cetraxate benzylesterase activity
           |   |__chlorogenate hydrolase activity
           |   |__chlorophyllase activity
           |   |__cholinesterase activity(+) 2 rec.
           |   |__cutinase activity
           |   |__D-arabinonolactonase activity
           |   |__deoxylimonate A-ring-lactonase activity
           |   |__dihydrocoumarin hydrolase activity
           |   |__diphthine methylesterase activity 1 rec.
           |   |__fatty-acyl-ethyl-ester synthase activity
           |   |__feruloyl esterase activity
           |   |__fusarinine-C ornithinesterase activity
           |   |__galactolipase activity
           |   |__gluconolactonase activity 3 rec.
           |   |__heparan sulfate N-deacetylase activity 1 rec.
           |   |__hydroxybutyrate-dimer hydrolase activity
           |   |__juvenile-hormone esterase activity 1 rec.
           |   |__L-arabinonolactonase activity
           |   |__L-ascorbate 6-phosphate lactonase activity
           |   |__L-rhamnono-1,4-lactonase activity
           |   |__L-seryl-tRNA(Thr) hydrolase activity
           |   |__lactonohydrolase activity(+)
           |   |__limonin-D-ring-lactonase activity
           |   |__methyl indole-3-acetate esterase activity
           |   |__methyl jasmonate esterase activity
           |   |__methyl salicylate esterase activity
           |   |__methylumbelliferyl-acetate deacetylase activity
           |   |__monoacylglycerol lipase activity 10 rec.
           |   |__mycophenolic acid acyl-glucuronide esterase activity
           |   |__N-acetylgalactosaminoglycan deacetylase activity
           |   |__O-acetyl-ADP-ribose deacetylase activity
           |   |__orsellinate-depside hydrolase activity
           |   |__palmitoleyl hydrolase activity 1 rec.
           |   |__pectin acetylesterase activity
           |   |__pectinesterase activity
           |   |__peptidyl-tRNA hydrolase activity 5 rec.
           |   |__pheophorbidase activity
           |   |__pheophytinase activity
           |   |__phorbol-diester hydrolase activity
           |   |__phosphatidylinositol deacylase activity
           |   |__pimelyl-[acyl-carrier protein] methyl ester esterase activity
           |   |__poly(3-hydroxybutyrate) depolymerase activity
           |   |__poly(3-hydroxyoctanoate) depolymerase activity
           |   |__polyneuridine-aldehyde esterase activity
           |   |__primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity
           |   |__protein methylesterase activity(+) 1 rec.
           |   |__retinyl-palmitate esterase activity(+)
           |   |__Ser(Gly)-tRNA(Ala) hydrolase activity
           |   |__short-chain carboxylesterase activity(+) 3 rec.
           |   |__sinapine esterase activity
           |   |__steroid-lactonase activity
           |   |__sterol ester esterase activity 3 rec.
           |   |__tannase activity
           |   |__trans-permethrin hydrolase activity
           |   |__triacetate-lactonase activity
           |   |__triacylglycerol lipase activity(+) 59 rec.
           |   |__tropinesterase activity
           |   |__uronolactonase activity
           |   |__vinylacetate caboxylester hydrolase activity
           |   |__wax-ester hydrolase activity
           |   |__xylono-1,4-lactonase activity
           |__deoxyribonuclease (pyrimidine dimer) activity
           |__DNA endonuclease activity, producing 3'-phosphomonoesters 5 rec.
           |   |__3'-flap endonuclease activity 1 rec.
           |   |__crossover junction DNA endonuclease activity 4 rec.
           |   |__deoxyribonuclease II activity 1 rec.
           |__DNA endonuclease activity, producing 5'-phosphomonoesters 13 rec.
           |   |__5'-flap endonuclease activity 6 rec.
           |   |__CC-preferring endodeoxyribonuclease activity
           |   |__class II DNA-(apurinic or apyrimidinic site) endonuclease activity 4 rec.
           |   |__deoxyribonuclease I activity 3 rec.
           |   |__deoxyribonuclease IV (phage-T4-induced) activity
           |   |__deoxyribonuclease V activity
           |   |__type I site-specific deoxyribonuclease activity
           |   |__type II site-specific deoxyribonuclease activity
           |   |__type III site-specific deoxyribonuclease activity
           |__double-stranded DNA endonuclease activity
           |   |__ds/ssDNA junction-specific dsDNA endonuclease activity
           |__double-stranded RNA-specific ribonuclease activity 4 rec.
           |   |__ribonuclease III activity 4 rec.
           |__enterochelin esterase activity
           |__excinuclease ABC activity
           |__exonuclease activity 57 rec.
           |   |__3'-5' exonuclease activity(+) 42 rec.
           |   |__5'-3' exonuclease activity(+) 13 rec.
           |   |__DNA exonuclease activity(+) 22 rec.
           |   |__phosphodiesterase I activity
           |   |__RNA exonuclease activity(+) 26 rec.
           |__flap endonuclease activity 8 rec.
           |   |__3'-flap endonuclease activity 1 rec.
           |   |__5'-flap endonuclease activity 6 rec.
           |__lipase activity 104 rec.
           |   |__diacylglycerol lipase activity
           |   |__galactolipase activity
           |   |__monoacylglycerol lipase activity 10 rec.
           |   |__phospholipase activity(+) 38 rec.
           |   |__sterol ester esterase activity 3 rec.
           |   |__triacylglycerol lipase activity(+) 59 rec.
           |__N-acetyltaurine hydrolase activity 1 rec.
           |__phosphoric ester hydrolase activity 253 rec.
           |   |__diphosphoric monoester hydrolase activity(+) 1 rec.
           |   |__phosphatase activity(+) 212 rec.
           |   |__phosphoric diester hydrolase activity(+) 39 rec.
           |   |__phosphoric triester hydrolase activity(+)
           |   |__triphosphoric monoester hydrolase activity(+) 1 rec.
           |__restriction endodeoxyribonuclease activity
           |   |__type I site-specific deoxyribonuclease activity
           |   |__type II site-specific deoxyribonuclease activity
           |   |__type III site-specific deoxyribonuclease activity
           |   |__type IV site-specific deoxyribonuclease activity
           |__retroviral 3' processing activity
           |__ribonuclease MRP activity 2 rec.
           |__RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
           |   |__ribonuclease F activity
           |   |__ribonuclease V activity
           |__RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism 22 rec.
           |   |__3'-tRNA processing endoribonuclease activity 1 rec.
           |   |__endoribonuclease activity, cleaving miRNA-paired mRNA 1 rec.
           |   |__endoribonuclease activity, cleaving siRNA-paired mRNA 1 rec.
           |   |__phosphodiesterase decapping endonuclease activity
           |   |__ribonuclease [poly-(U)-specific] activity
           |   |__ribonuclease E activity
           |   |__ribonuclease III activity 4 rec.
           |   |__ribonuclease IV activity
           |   |__ribonuclease IX activity
           |   |__ribonuclease M5 activity
           |   |__ribonuclease P activity 5 rec.
           |   |__ribonuclease P4 activity
           |   |__RNA lariat debranching enzyme activity 1 rec.
           |   |__RNA-(apurinic or apyrimidinic site) endonuclease activity
           |   |__RNA-DNA hybrid ribonuclease activity 6 rec.
           |__single-stranded DNA endodeoxyribonuclease activity 4 rec.
           |   |__3' overhang single-stranded DNA endodeoxyribonuclease activity 1 rec.
           |   |__5' overhang single-stranded DNA endodeoxyribonuclease activity
           |__sulfuric ester hydrolase activity 12 rec.
           |   |__arylsulfatase activity
           |   |__cellulose-polysulfatase activity
           |   |__cerebroside-sulfatase activity
           |   |__choline-sulfatase activity
           |   |__chondro-4-sulfatase activity
           |   |__chondro-6-sulfatase activity
           |   |__D-lactate-2-sulfatase activity
           |   |__disulfoglucosamine-6-sulfatase activity
           |   |__glucuronate-2-sulfatase activity
           |   |__glycosulfatase activity
           |   |__iduronate-2-sulfatase activity 1 rec.
           |   |__linear primary-alkylsulfatase activity
           |   |__monomethyl-sulfatase activity
           |   |__N-acetylgalactosamine-4-sulfatase activity 5 rec.
           |   |__N-acetylgalactosamine-6-sulfatase activity
           |   |__N-acetylglucosamine-6-sulfatase activity 4 rec.
           |   |__N-sulfoglucosamine-3-sulfatase activity
           |   |__steryl-sulfatase activity
           |__thiolester hydrolase activity 20 rec.
           |   |__[citrate-(pro-3S)-lyase] thiolesterase activity
           |   |__acyl-CoA hydrolase activity(+) 10 rec.
           |   |__fatty acyl-[ACP] hydrolase activity
           |   |__glutathione thiolesterase activity
           |   |__hydroxyacylglutathione hydrolase activity 1 rec.
           |   |__palmitoyl-(protein) hydrolase activity 6 rec.
           |   |__S-formylglutathione hydrolase activity 1 rec.
           |   |__S-succinylglutathione hydrolase activity
           |__versiconal hemiacetal acetate esterase activity
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Synonyms
  • "esterase activity" EXACT
Secondary IDs
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EC:3.1.-.-
Reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid"
Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin"
Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin"
Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-"