FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term thiolester hydrolase activity ID (Ontology) GO:0016790 (Gene Ontology)
Definition Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.[ EC:3 ]
Also Known As"thiolesterase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 thiolester hydrolase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | thiolester hydrolase activity       --
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  hydrolase activity
   |__hydrolase activity, acting on ester bonds
       |__thiolester hydrolase activity  20 rec.
           |__[citrate-(pro-3S)-lyase] thiolesterase activity
           |__acyl-CoA hydrolase activity 10 rec.
           |   |__(S)-methylmalonyl-CoA hydrolase activity
           |   |__1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
           |   |__4-hydroxybenzoyl-CoA thioesterase activity
           |   |__acetoacetyl-CoA hydrolase activity
           |   |__acetyl-CoA hydrolase activity 4 rec.
           |   |__choloyl-CoA hydrolase activity
           |   |__fatty acyl-CoA hydrolase activity(+) 9 rec.
           |   |__hydroxymethylglutaryl-CoA hydrolase activity
           |   |__phenylacetyl-CoA hydrolase activity
           |   |__succinyl-CoA hydrolase activity
           |__fatty acyl-[ACP] hydrolase activity
           |__glutathione thiolesterase activity
           |__hydroxyacylglutathione hydrolase activity 1 rec.
           |__palmitoyl-(protein) hydrolase activity 6 rec.
           |__S-formylglutathione hydrolase activity 1 rec.
           |__S-succinylglutathione hydrolase activity
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Is a hydrolase activity, acting on ester bonds
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Synonyms
  • "thiolesterase activity" EXACT
Secondary IDs
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EC:3.1.2.-