FB2026_03 , released September 17, 2026
CV Term Report
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Term aldehyde-lyase activity ID (Ontology) GO:0016832 (Gene Ontology)
Definition Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
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 aldehyde-lyase activity (all annotations which use CV term, excluding "NOT" statements)
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  lyase activity
   |__carbon-carbon lyase activity
       |__aldehyde-lyase activity  7 rec.
           |__(S)-hydroxynitrile lyase activity
           |   |__aliphatic (S)-hydroxynitrile lyase activity
           |   |__aromatic (S)-hydroxynitrile lyase activity
           |__2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
           |__2-dehydro-3-deoxy-D-gluconate aldolase activity
           |__2-dehydro-3-deoxy-D-pentonate aldolase activity
           |__2-dehydro-3-deoxy-L-pentonate aldolase activity
           |__2-dehydro-3-deoxy-phosphogluconate aldolase activity
           |__2-dehydro-3-deoxyglucarate aldolase activity
           |__2-dehydropantoate aldolase activity
           |__2-hydroxyacyl-CoA lyase activity 1 rec.
           |   |__2-hydroxyphytanoyl-CoA lyase activity
           |__2-keto-3-deoxy-L-rhamnonate aldolase activity
           |__3-deoxy-D-manno-octulosonate aldolase activity
           |__4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
           |__4-hydroxy-2-ketopimelate aldolase activity
           |__4-hydroxy-L-threonine aldolase activity
           |__5-dehydro-2-deoxyphosphogluconate aldolase activity
           |__6-carboxytetrahydropterin synthase activity
           |__6-deoxy-6-sulfofructose-1-phosphate aldolase activity
           |__7,8-dihydromonapterin aldolase activity
           |__aliphatic (R)-hydroxynitrile lyase activity
           |__benzoin aldolase activity
           |__D-threonine aldolase activity
           |__deoxyribose-phosphate aldolase activity 1 rec.
           |__dihydroneopterin aldolase activity
           |__dimethylaniline-N-oxide aldolase activity
           |__feruloyl-CoA hydratase/lyase activity
           |__fructose 6-phosphate aldolase activity
           |__fructose-1-phosphate aldolase activity 1 rec.
           |__fructose-6-phosphate phosphoketolase activity
           |__fructose-bisphosphate aldolase activity 1 rec.
           |__fucosterol-epoxide lyase activity
           |__hexulose-6-phosphate synthase activity
           |__hydroxymandelonitrile lyase activity
           |__hydroxytrimethyllysine aldolase activity 2 rec.
           |__indole-3-glycerol-phosphate lyase activity
           |__ketotetrose-phosphate aldolase activity
           |__L-fuculose-phosphate aldolase activity
           |__lactate aldolase activity
           |__mandelonitrile lyase activity
           |__phenylserine aldolase activity
           |__phosphoketolase activity
           |__propioin synthase activity
           |__rhamnulose-1-phosphate aldolase activity
           |__sphinganine-1-phosphate aldolase activity 1 rec.
           |__tagatose-bisphosphate aldolase activity
           |__threonine aldolase activity 1 rec.
           |   |__L-allo-threonine aldolase activity 1 rec.
           |__trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
           |__trimethylamine-oxide aldolase activity
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Is a carbon-carbon lyase activity
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Synonyms
  • "aldolase activity" BROAD
Secondary IDs
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EC:4.1.2.-
Reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine"
Reactome:R-HSA-200735 "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG"
Reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly"