FB2026_03 , released September 17, 2026
CV Term Report
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Term carbon-nitrogen lyase activity ID (Ontology) GO:0016840 (Gene Ontology)
Definition Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH4+, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).[ EC:4 ]
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 carbon-nitrogen lyase activity (all annotations which use CV term, excluding "NOT" statements)
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  catalytic activity
   |__lyase activity
       |__carbon-nitrogen lyase activity  14 rec.
           |__amidine-lyase activity 11 rec.
           |   |__(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity 1 rec.
           |   |__argininosuccinate lyase activity 1 rec.
           |   |__gamma-glutamylaminecyclotransferase activity 2 rec.
           |   |__gamma-glutamylcyclotransferase activity 2 rec.
           |   |__glutathione specific gamma-glutamylcyclotransferase activity 2 rec.
           |   |__N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity 1 rec.
           |   |__peptidylamidoglycolate lyase activity 2 rec.
           |   |__purine imidazole-ring cyclase activity
           |   |__ureidoglycolate lyase activity
           |__amine-lyase activity
           |   |__3-ketovalidoxylamine C-N-lyase activity
           |   |__4-hydroxy-tetrahydrodipicolinate synthase activity
           |   |__mimosinase activity
           |   |__pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
           |__ammonia-lyase activity 2 rec.
           |   |__3-aminobutyryl-CoA ammonia-lyase activity
           |   |__7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
           |   |__ADP-riboxanase-[protein] activity
           |   |__aspartate ammonia-lyase activity
           |   |__beta-alanyl-CoA ammonia-lyase activity
           |   |__carbamoyl-serine ammonia-lyase activity
           |   |__D-serine ammonia-lyase activity 1 rec.
           |   |__diaminopropionate ammonia-lyase activity
           |   |__erythro-3-hydroxyaspartate ammonia-lyase activity
           |   |__ethanolamine ammonia-lyase activity
           |   |__formimidoyltetrahydrofolate cyclodeaminase activity
           |   |__glucosaminate ammonia-lyase activity
           |   |__histidine ammonia-lyase activity
           |   |__L-serine ammonia-lyase activity 1 rec.
           |   |__methylaspartate ammonia-lyase activity
           |   |__ornithine cyclodeaminase activity
           |   |__phenylalanine ammonia-lyase activity
           |   |__serine-sulfate ammonia-lyase activity
           |   |__threo-3-hydroxyaspartate ammonia-lyase activity
           |   |__threonine deaminase activity 1 rec.
           |   |__tyrosine ammonia-lyase activity
           |__choline trimethylamine lyase activity
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  • "other carbon-nitrogen lyase activity" NARROW
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EC:4.3.-.-