FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term lipoate synthase activity ID (Ontology) GO:0016992 (Gene Ontology)
Definition Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin].
Also Known As "lipoic acid synthase"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 lipoate synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | lipoate synthase activity
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Vocabulary search: maintenance 
  transferase activity, transferring sulphur-containing groups
   |__sulfurtransferase activity
       |__lipoate synthase activity  1 rec.
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Is a sulfurtransferase activity
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Synonyms
  • "LipA" RELATED[ EC:2 ]
    "lipoic acid synthase" EXACT
    "lipoyl synthase activity" RELATED[ EC:2 ]
    "LS" RELATED[ EC:2 ]
    "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" RELATED[ EC:2 ]
    "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.8.1.8
MetaCyc:RXN-14950
MetaCyc:RXN-14957
MetaCyc:RXN-14959
MetaCyc:RXN0-949
Reactome:R-HSA-6793591 "LIAS synthesizes lipoyl-GCSH"
RHEA:16585