FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term N-acylsphingosine amidohydrolase activity ID (Ontology) GO:0017040 (Gene Ontology)
Definition Catalysis of the reaction: an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine.
Comment
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 N-acylsphingosine amidohydrolase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | N-acylsphingosine amidohydrolase activity
 NOT | enables | N-acylsphingosine amidohydrolase activity
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  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
   |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
       |__N-acylsphingosine amidohydrolase activity  1 rec.
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Is a hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
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Synonyms
  • "acylsphingosine deacylase activity" RELATED[ EC:3 ]
    "ceramidase activity" NARROW
    "glycosphingolipid ceramide deacylase" BROAD[ EC:3 ]
Secondary IDs
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EC:3.5.1.23
MetaCyc:CERAMIDASE-RXN
Reactome:R-HSA-1606583 "ASAH2 hydrolyzes ceramide (plasma membrane)"
Reactome:R-HSA-1606602 "ASAH1 hydrolyzes ceramide"
Reactome:R-HSA-428205 "ACER2 hydrolyzes ceramide (Golgi)"
Reactome:R-HSA-428231 "ACER1 hydrolyzes ceramide (endoplasmic reticulum)"
Reactome:R-HSA-428262 "ACER3 hydrolyzes phytoceramide"
RHEA:20856
RHEA:38891
RHEA:41267
RHEA:41275
RHEA:41279
RHEA:41283
RHEA:41287
RHEA:41291
RHEA:41295
RHEA:41299
RHEA:45092
RHEA:45348
RHEA:45356
RHEA:58484