FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

negative cofactor 2 complex

ID (Ontology)

GO:0017054 (Gene Ontology)

Definition

A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.[ PubMed:15574413 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
negative cofactor 2 complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| negative cofactor 2 complex

Spanning Tree (Parents/Children)

transcription repressor complex_____
nuclear protein-containing complex__|
                                    RNA polymerase II transcription repressor complex
                                     |__negative cofactor 2 complex  2 rec.

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Relationships
Is a	RNA polymerase II transcription repressor complex
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts