FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term aminoacyl-tRNA synthetase multienzyme complex ID (Ontology) GO:0017101 (Gene Ontology)
Definition A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.[ PubMed:16169847 ]
Also Known As "aminoacyl-tRNA synthetase complex" ; "multisynthetase complex"
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT      11
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 Genes
 aminoacyl-tRNA synthetase multienzyme complex (all annotations which use CV term, excluding "NOT" statements)      11
     part_of | aminoacyl-tRNA synthetase multienzyme complex      11
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protein-containing complex
 |__intracellular protein-containing complex__
 |__catalytic complex_________________________|
                                              aminoacyl-tRNA synthetase multienzyme complex  11 rec.
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Is a intracellular protein-containing complex
catalytic complex
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Synonyms
  • "aminoacyl-tRNA synthetase complex" EXACT
    "multisynthetase complex" EXACT
Secondary IDs
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