FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term 5'-flap endonuclease activity ID (Ontology) GO:0017108 (Gene Ontology)
Definition Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.[ PubMed:9778254 ]
Also Known As "5' flap endonuclease activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 5'-flap endonuclease activity (all annotations which use CV term, excluding "NOT" statements)       3
     enables | 5'-flap endonuclease activity       3
Spanning Tree (Parents/Children)
Only view relationship: 
DNA endonuclease activity
 |__DNA endonuclease activity, producing 5'-phosphomonoesters__
 |__flap endonuclease activity_________________________________|
hydrolase activity, acting on ester bonds                      |
 |__DNA endonuclease activity, producing 5'-phosphomonoesters__|
 |__flap endonuclease activity_________________________________|
                                                               5'-flap endonuclease activity  3 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a DNA endonuclease activity, producing 5'-phosphomonoesters
flap endonuclease activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "5' flap endonuclease activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA"
Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand"
Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)"
Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ"
Reactome:R-HSA-69152 "Removal of remaining Flap"
Reactome:R-HSA-9914870 "MGME1 cleaves 5' DNA flap from nascent mitochondrial DNA"