FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

5'-flap endonuclease activity

ID (Ontology)

GO:0017108 (Gene Ontology)

Definition

Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.[ PubMed:9778254 ]

Also Known As

"5' flap endonuclease activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
5'-flap endonuclease activity (all annotations which use CV term, excluding "NOT" statements)
enables \| 5'-flap endonuclease activity

Spanning Tree (Parents/Children)

DNA endonuclease activity
 |__DNA endonuclease activity, producing 5'-phosphomonoesters__
 |__flap endonuclease activity_________________________________|
hydrolase activity, acting on ester bonds                      |
 |__DNA endonuclease activity, producing 5'-phosphomonoesters__|
 |__flap endonuclease activity_________________________________|
                                                               5'-flap endonuclease activity  6 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA endonuclease activity, producing 5'-phosphomonoesters flap endonuclease activity
Part of
Synonyms & Secondary IDs
Synonyms
	"5' flap endonuclease activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA" Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand" Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)" Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ" Reactome:R-HSA-69152 "Removal of remaining Flap" Reactome:R-HSA-9914870 "MGME1 cleaves 5' DNA flap from nascent mitochondrial DNA"