FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term dihydropyrimidine dehydrogenase (NADP+) activity ID (Ontology) GO:0017113 (Gene Ontology)
Definition Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.[ EC:1 ]
Also Known As"dihydropyrimidine dehydrogenase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 dihydropyrimidine dehydrogenase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | dihydropyrimidine dehydrogenase (NADP+) activity
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  oxidoreductase activity, acting on the CH-CH group of donors
   |__oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
       |__dihydropyrimidine dehydrogenase (NADP+) activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
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Synonyms
  • "4,5-dihydrothymine: oxidoreductase activity" RELATED[ EC:1 ]
    "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" RELATED[ EC:1 ]
    "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" RELATED[ EC:1 ]
    "DHPDH" RELATED[ EC:1 ]
    "DHU dehydrogenase activity" RELATED[ EC:1 ]
    "dihydropyrimidine dehydrogenase activity" EXACT
    "dihydrothymine dehydrogenase activity" RELATED[ EC:1 ]
    "dihydrouracil dehydrogenase (NADP)" RELATED[ EC:1 ]
    "dihydrouracil dehydrogenase (NADP+) activity" RELATED[ EC:1 ]
    "DPD" RELATED[ EC:1 ]
    "hydropyrimidine dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.3.1.2
MetaCyc:1.3.1.2-RXN
Reactome:R-HSA-73585 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+"
Reactome:R-HSA-73616 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+"
RHEA:18093