FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term histone deacetylase activity, NAD-dependent ID (Ontology) GO:0017136 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide.[ PubMed:24691964 PubMed:28450737 ]
Also Known As "NAD-dependent histone deacetylase activity" ; "NAD-dependent histone lysine deacetylase activity"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       5
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Relevant FlyBase reports
 Gene Groups Genes
 histone deacetylase activity, NAD-dependent (all annotations which use CV term, excluding "NOT" statements)       1      5
     enables | histone deacetylase activity, NAD-dependent       --       5
Spanning Tree (Parents/Children)
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protein lysine deacetylase activity
 |__histone deacetylase activity_______________________
histone modifying activity                             |
 |__histone deacetylase activity_______________________|
NAD-dependent protein lysine deacylase activity        |
 |__NAD-dependent protein lysine deacetylase activity__|
                                                       histone deacetylase activity, NAD-dependent  6 rec.
                                                        |__histone H3K4 deacetylase activity, NAD-dependent
                                                        |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                                        |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                                        |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                                        |__histone H3K56 deacetylase activity, NAD-dependent
                                                        |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.
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Is a histone deacetylase activity
NAD-dependent protein lysine deacetylase activity
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Synonyms
  • "histone deacetylase activity" BROAD
    "NAD-dependent histone deacetylase activity" EXACT
    "NAD-dependent histone lysine deacetylase activity" EXACT
    "SIR2" RELATED
    "sirtuin" NARROW
Secondary IDs
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