FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

histone deacetylase activity, NAD-dependent

ID (Ontology)

GO:0017136 (Gene Ontology)

Definition

Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide.[ PubMed:24691964 PubMed:28450737 ]

Also Known As

"NAD-dependent histone deacetylase activity" ; "NAD-dependent histone lysine deacetylase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
histone deacetylase activity, NAD-dependent (all annotations which use CV term, excluding "NOT" statements)
enables \| histone deacetylase activity, NAD-dependent	--

Spanning Tree (Parents/Children)

protein lysine deacetylase activity
 |__histone deacetylase activity_______________________
histone modifying activity                             |
 |__histone deacetylase activity_______________________|
NAD-dependent protein lysine deacylase activity        |
 |__NAD-dependent protein lysine deacetylase activity__|
                                                       histone deacetylase activity, NAD-dependent  6 rec.
                                                        |__histone H3K4 deacetylase activity, NAD-dependent
                                                        |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                                        |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                                        |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                                        |__histone H3K56 deacetylase activity, NAD-dependent
                                                        |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	histone deacetylase activity NAD-dependent protein lysine deacetylase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"histone deacetylase activity" BROAD "NAD-dependent histone deacetylase activity" EXACT "NAD-dependent histone lysine deacetylase activity" EXACT "SIR2" RELATED "sirtuin" NARROW
Secondary IDs

External Crossreferences & Linkouts