FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

NMDA selective glutamate receptor complex

ID (Ontology)

GO:0017146 (Gene Ontology)

Definition

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.[ PubMed:8294079 ]

Also Known As

"N-methyl-D-aspartate selective glutamate receptor complex" ; "NMDA-selective glutamate receptor"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
NMDA selective glutamate receptor complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| NMDA selective glutamate receptor complex

Spanning Tree (Parents/Children)

monoatomic ion channel complex_____
neurotransmitter receptor complex__|
                                   ionotropic glutamate receptor complex
                                    |__NMDA selective glutamate receptor complex  1 rec.

Spanning Tree View Settings
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Relationships
Is a	ionotropic glutamate receptor complex
Part of
Synonyms & Secondary IDs
Synonyms
	"N-methyl-D-aspartate selective glutamate receptor complex" EXACT "NMDA-selective glutamate receptor" EXACT
Secondary IDs

External Crossreferences & Linkouts