FB2026_03 , released September 17, 2026
CV Term Report
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Term tRNA dihydrouridine synthase activity ID (Ontology) GO:0017150 (Gene Ontology)
Definition Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H.[ PubMed:11983710 PubMed:22123979 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tRNA dihydrouridine synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA dihydrouridine synthase activity       --
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oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
 |__RNA dihydrouridine synthase activity__
catalytic activity, acting on RNA         |
 |__catalytic activity, acting on a tRNA__|
                                          tRNA dihydrouridine synthase activity  5 rec.
                                           |__tRNA-dihydrouridine16 synthase activity 1 rec.
                                           |__tRNA-dihydrouridine17 synthase activity 1 rec.
                                           |__tRNA-dihydrouridine20 synthase activity 1 rec.
                                           |__tRNA-dihydrouridine20a synthase activity 1 rec.
                                           |__tRNA-dihydrouridine20b synthase activity 1 rec.
                                           |__tRNA-dihydrouridine47 synthase activity 1 rec.
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Is a RNA dihydrouridine synthase activity
catalytic activity, acting on a tRNA
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MetaCyc:RXN0-1281
Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs"
RHEA:23624
RHEA:53336
RHEA:53340
RHEA:53360
RHEA:53364
RHEA:54452