FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term 5-oxoprolinase (ATP-hydrolyzing) activity ID (Ontology) GO:0017168 (Gene Ontology)
Definition Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate.[ EC:3 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 5-oxoprolinase (ATP-hydrolyzing) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 5-oxoprolinase (ATP-hydrolyzing) activity
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
   |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
       |__5-oxoprolinase (ATP-hydrolyzing) activity  1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "5-OPase activity" RELATED[ EC:3 ]
    "5-oxo-L-prolinase activity" RELATED[ EC:3 ]
    "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" RELATED[ EC:3 ]
    "5-oxoprolinase (ATP-hydrolysing)" RELATED[ EC:3 ]
    "5-oxoprolinase activity" RELATED[ EC:3 ]
    "L-pyroglutamate hydrolase activity" RELATED[ EC:3 ]
    "oxoprolinase activity" RELATED[ EC:3 ]
    "pyroglutamase (ATP-hydrolysing)" RELATED[ EC:3 ]
    "pyroglutamase (ATP-hydrolyzing) activity" RELATED[ EC:3 ]
    "pyroglutamase activity" RELATED[ EC:3 ]
    "pyroglutamate hydrolase activity" RELATED[ EC:3 ]
    "pyroglutamic hydrolase activity" RELATED[ EC:3 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.5.2.9
KEGG_REACTION:R00251
MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN
Reactome:R-HSA-1247935 "OPLAH hydrolyses OPRO to L-Glu"
Reactome:R-HSA-5603208 "Defective OPLAH does not hydrolyse OPRO"
RHEA:10348
Wikipedia:5-oxoprolinase_(ATP-hydrolysing)