FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein histidyl modification to diphthamide ID (Ontology) GO:0017183 (Gene Ontology)
Definition The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.[ PubMed:20559380 ]
Also Known As"peptidyl-diphthamide anabolism from peptidyl-histidine" ; "peptidyl-diphthamide biosynthetic process from peptidyl-histidine" ; "peptidyl-diphthamide formation from peptidyl-histidine" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 protein histidyl modification to diphthamide (all annotations which use CV term, excluding "NOT" statements)
     involved_in | protein histidyl modification to diphthamide       --
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protein metabolic process___
macromolecule modification__|
                            protein modification process
                             |__protein histidyl modification to diphthamide  8 rec.
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Synonyms
  • "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT
    "peptidyl-diphthamide biosynthetic process from peptidyl-histidine" EXACT
    "peptidyl-diphthamide formation from peptidyl-histidine" EXACT
    "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT
Secondary IDs
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Reactome:R-HSA-5358493 "Synthesis of diphthamide-EEF2"
RESID:AA0040