FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 3-hydroxyacyl-CoA dehydratase activity ID (Ontology) GO:0018812 (Gene Ontology)
Definition Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 3-hydroxyacyl-CoA dehydratase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 3-hydroxyacyl-CoA dehydratase activity
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  hydro-lyase activity
   |__enoyl-CoA hydratase activity
       |__3-hydroxyacyl-CoA dehydratase activity  4 rec.
           |__(2E)-butenoyl-CoA hydratase activity 1 rec.
           |__(2E)-enoyl-CoA hydratase activity 3 rec.
               |__very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity 2 rec.
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Is a enoyl-CoA hydratase activity
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Synonyms
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EC:4.2.1.150
EC:4.2.1.74
MetaCyc:ENOYL-COA-HYDRAT-RXN
Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA"
Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA"
Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA"
Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA"
Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA"
Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA"
Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA"
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