FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term DNA N-glycosylase activity ID (Ontology) GO:0019104 (Gene Ontology)
Definition Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.[ PubMed:11554296 ]
Also Known As "DNA glycosylase activity"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 DNA N-glycosylase activity (all annotations which use CV term, excluding "NOT" statements)       1      2
     enables | DNA N-glycosylase activity       --       2
Spanning Tree (Parents/Children)
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hydrolase activity, acting on glycosyl bonds
 |__hydrolase activity, hydrolyzing N-glycosyl compounds__
catalytic activity, acting on a nucleic acid              |
 |__catalytic activity, acting on DNA_____________________|
                                                          DNA N-glycosylase activity  6 rec.
                                                           |__alkylbase DNA N-glycosylase activity
                                                           |   |__DNA-1,N6-ethenoadenine N-glycosylase activity
                                                           |   |__DNA-3-methylbase glycosylase activity(+)
                                                           |   |__DNA-5-methylcytosine glycosylase activity
                                                           |   |__DNA-7-methyladenine glycosylase activity
                                                           |   |__DNA-7-methylguanine glycosylase activity
                                                           |__deaminated base DNA N-glycosylase activity 2 rec.
                                                           |   |__hypoxanthine DNA N-glycosylase activity
                                                           |   |__oxanine DNA N-glycosylase activity
                                                           |   |__uracil DNA N-glycosylase activity(+) 2 rec.
                                                           |   |__xanthine DNA N-glycosylase activity
                                                           |__mismatch base pair DNA N-glycosylase activity 1 rec.
                                                           |   |__purine-specific mismatch base pair DNA N-glycosylase activity
                                                           |   |__pyrimidine-specific mismatch base pair DNA N-glycosylase activity(+) 1 rec.
                                                           |__oxidized base lesion DNA N-glycosylase activity 4 rec.
                                                           |   |__oxidized purine nucleobase lesion DNA N-glycosylase activity(+) 2 rec.
                                                           |   |__oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(+) 2 rec.
                                                           |__pyrimidine dimer DNA N-glycosylase activity
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Is a hydrolase activity, hydrolyzing N-glycosyl compounds
catalytic activity, acting on DNA
Part of
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Synonyms
  • "DNA glycosylase activity" EXACT
    "endonuclease VIII activity" RELATED
Secondary IDs
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Reactome:R-HSA-110218 "Cleavage of uracil by TDG glycosylase"
Reactome:R-HSA-110219 "Cleavage of thymine by TDG glycosylase"
Reactome:R-HSA-110231 "Cleavage of uracil by MBD4 glycosylase"
Reactome:R-HSA-110232 "Cleavage of thymine by MBD4 glycosylase"
Reactome:R-HSA-110234 "Cleavage of ethenocytosine by TDG glycosylase"
Reactome:R-HSA-110246 "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH"
Reactome:R-HSA-110248 "Cleavage of 3-methyladenine by MPG glycosylase"
Reactome:R-HSA-110250 "Cleavage of ethenoadenine by MPG glycosylase"
Reactome:R-HSA-110251 "Cleavage of hypoxanthine by MPG glycosylase"
Reactome:R-HSA-5220959 "TDG excises 5-formylcytosine"
Reactome:R-HSA-5221061 "TDG excises 5-carboxylcytosine"
Reactome:R-HSA-5649658 "NEIL1 cleaves DHU from damaged DNA"
Reactome:R-HSA-5649664 "NEIL1 cleaves FapyG from damaged DNA"
Reactome:R-HSA-5649673 "NEIL1 cleaves FapyA from damaged DNA"
Reactome:R-HSA-5649681 "NEIL2 cleaves 5-OHU from damaged DNA"
Reactome:R-HSA-9629149 "NEIL1 cleaves thymine glycol from damaged DNA"
Reactome:R-HSA-9629216 "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA"
Reactome:R-HSA-9629470 "NEIL3 cleaves 5-guanidinohydantoin"
Reactome:R-HSA-9629483 "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA"
Reactome:R-HSA-9629492 "NEIL3 cleaves spiroiminodihydantoin"
Reactome:R-HSA-9629497 "NEIL3 cleaves thymine glycol from telomeric DNA"
Reactome:R-HSA-9629499 "NEIL3 cleaves thymine glycol"
Reactome:R-HSA-9635996 "NEIL3 resolves psoralen-induced ICLs"
Reactome:R-HSA-9636008 "NEIL3 resolves abasic site-induced ICLs"