FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term deoxyhypusine monooxygenase activity ID (Ontology) GO:0019135 (Gene Ontology)
Definition Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.[ EC:1 ]
Also Known As"deoxyhypusine hydroxylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 deoxyhypusine monooxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | deoxyhypusine monooxygenase activity
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catalytic activity
 |__catalytic activity, acting on a protein________________________________________________________________
oxidoreductase activity                                                                                    |
 |__monooxygenase activity_________________________________________________________________________________|
 |__oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         deoxyhypusine monooxygenase activity  1 rec.
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Is a monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
catalytic activity, acting on a protein
Part of
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Synonyms
  • "deoxyhypusine dioxygenase activity" RELATED[ EC:1 ]
    "deoxyhypusine hydroxylase activity" EXACT
    "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" RELATED[ EC:1 ]
    "DOHH activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.99.29
MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN
Reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A"
RHEA:14101