FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term transmembrane receptor protein kinase activity ID (Ontology) GO:0019199 (Gene Ontology)
Definition Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 transmembrane receptor protein kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | transmembrane receptor protein kinase activity
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kinase activity
 |__protein kinase activity_____________________________
phosphotransferase activity, alcohol group as acceptor  |
 |__protein kinase activity_____________________________|
signaling receptor activity                             |
 |__transmembrane signaling receptor activity___________|
catalytic activity, acting on a protein                 |
 |__protein kinase activity_____________________________|
                                                        transmembrane receptor protein kinase activity  26 rec.
                                                         |__transmembrane receptor histidine kinase activity
                                                         |   |__transmembrane histidine kinase cytokinin receptor activity
                                                         |__transmembrane receptor protein serine/threonine kinase activity 8 rec.
                                                         |   |__activin receptor activity(+) 4 rec.
                                                         |   |__BMP receptor activity 4 rec.
                                                         |   |__transforming growth factor beta receptor activity(+) 2 rec.
                                                         |__transmembrane receptor protein tyrosine kinase activity 18 rec.
                                                             |__boss receptor activity 1 rec.
                                                             |__brain-derived neurotrophic factor receptor activity
                                                             |__ephrin receptor activity(+) 1 rec.
                                                             |__epidermal growth factor receptor activity 1 rec.
                                                             |__fibroblast growth factor receptor activity 2 rec.
                                                             |__hepatocyte growth factor receptor activity
                                                             |__insulin receptor activity 1 rec.
                                                             |__insulin-like growth factor receptor activity
                                                             |__macrophage colony-stimulating factor receptor activity
                                                             |__placental growth factor receptor activity
                                                             |__platelet-derived growth factor receptor activity(+)
                                                             |__protein tyrosine kinase collagen receptor activity 1 rec.
                                                             |__stem cell factor receptor activity
                                                             |__vascular endothelial growth factor receptor activity
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Is a protein kinase activity
transmembrane signaling receptor activity
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Reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex"
Reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated"