FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

isopentenyl diphosphate biosynthetic process, mevalonate pathway

ID (Ontology)

GO:0019287 (Gene Ontology)

Definition

The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.

Also Known As

"Ac-MVA pathway" ; "acetate-mevalonate pathway" ; "isopentenyl diphosphate anabolism, mevalonate pathway" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
isopentenyl diphosphate biosynthetic process, mevalonate pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| isopentenyl diphosphate biosynthetic process, mevalonate pathway

Spanning Tree (Parents/Children)

acyl-CoA metabolic process
 |__acetyl-CoA metabolic process__________________
isoprenoid biosynthetic process                   |
 |__isopentenyl diphosphate biosynthetic process__|
phospholipid biosynthetic process                 |
 |__isopentenyl diphosphate biosynthetic process__|
isopentenyl diphosphate metabolic process         |
 |__isopentenyl diphosphate biosynthetic process__|
                                                  isopentenyl diphosphate biosynthetic process, mevalonate pathway  3 rec.
                                                   |__regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
                                                       |__negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
                                                       |__positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	acetyl-CoA metabolic process isopentenyl diphosphate biosynthetic process
Part of
Synonyms & Secondary IDs
Synonyms
	"Ac-MVA pathway" EXACT[ PubMed:14517367 ] "acetate-mevalonate pathway" EXACT[ PubMed:14517367 ] "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT "isopentenyl diphosphate formation, mevalonate pathway" EXACT "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT "mevalonate pathway" EXACT "MVA pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts
	MetaCyc:PWY-6174 MetaCyc:PWY-7524 MetaCyc:PWY-8125 MetaCyc:PWY-922