FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term deNEDDylase activity ID (Ontology) GO:0019784 (Gene Ontology)
Definition An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.[ PubMed:25628956 ]
Also Known As "NEDD8-specific protease activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 deNEDDylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | deNEDDylase activity       --
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  peptidase activity
   |__ubiquitin-like protein peptidase activity
       |__deNEDDylase activity  8 rec.
           |__cysteine-type deNEDDylase activity 2 rec.
           |__metal-dependent deNEDDylase activity 2 rec.
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Is a ubiquitin-like protein peptidase activity
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Synonyms
  • "NEDD8-specific protease activity" EXACT
Secondary IDs
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Reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8"
Reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2"
Reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes"
Reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex"