FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term deNEDDylase activity ID (Ontology) GO:0019784 (Gene Ontology)
Definition An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.[ PubMed:25628956 ]
Also Known As "NEDD8-specific protease activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 deNEDDylase activity (all annotations which use CV term, excluding "NOT" statements)       4      2
     enables | deNEDDylase activity       --       2
Spanning Tree (Parents/Children)
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  peptidase activity
   |__ubiquitin-like protein peptidase activity
       |__deNEDDylase activity  8 rec.
           |__cysteine-type deNEDDylase activity 2 rec.
           |__metal-dependent deNEDDylase activity 2 rec.
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Is a ubiquitin-like protein peptidase activity
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Synonyms
  • "NEDD8-specific protease activity" EXACT
Secondary IDs
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Reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8"
Reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2"
Reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes"
Reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex"