FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term SUMO transferase activity ID (Ontology) GO:0019789 (Gene Ontology)
Definition Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.[ PubMed:11031248 PubMed:11265250 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      10
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 SUMO transferase activity (all annotations which use CV term, excluding "NOT" statements)       1     10
     enables | SUMO transferase activity       --      10
Spanning Tree (Parents/Children)
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aminoacyltransferase activity____________
catalytic activity, acting on a protein__|
                                         ubiquitin-like protein transferase activity
                                          |__SUMO transferase activity  15 rec.
                                              |__SUMO conjugating enzyme activity 1 rec.
                                              |__SUMO ligase activity 7 rec.
                                                  |__SUMO-ubiquitin ligase activity
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Is a ubiquitin-like protein transferase activity
Part of
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Synonyms
  • "SMT3 conjugating enzyme" RELATED
    "SUMO conjugating enzyme activity" RELATED
Secondary IDs
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Reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)"
Reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)"
Reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)"
Reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3"
Reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3"
Reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1"
Reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1"
Reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2"
Reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1"
Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1"
Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2"
Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3"
Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1"
Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2"
Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3"
Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1"
Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1"
Reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1"
Reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1"
Reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1"
Reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1"
Reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1"
Reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1"
Reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3"
Reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1"
Reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1"
Reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1"
Reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1"
Reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1"
Reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2"
Reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1"
Reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1"
Reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1"
Reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1"
Reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1"
Reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1"
Reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1"
Reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1"
Reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1"
Reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1"
Reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1"
Reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3"
Reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1"
Reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1"
Reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1"
Reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3"
Reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1"
Reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1"
Reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1"
Reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1"
Reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1"
Reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1"
Reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1"
Reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1"
Reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1"
Reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1"
Reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1"
Reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2"
Reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1"
Reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2"
Reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1"
Reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2"
Reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1"
Reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3"
Reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1"
Reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1"
Reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1"
Reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1"
Reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2"
Reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1"
Reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1"
Reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1"
Reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1"
Reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3"
Reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3"
Reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1"
Reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1"
Reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1"
Reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3"
Reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3"
Reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1"
Reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3"
Reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2"
Reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1"
Reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1"
Reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2"
Reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1"
Reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3"
Reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1"
Reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3"
Reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1"
Reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1"
Reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1"
Reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3"
Reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1"
Reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1"
Reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1"
Reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3"
Reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1"
Reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1"
Reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1"
Reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3"
Reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1"
Reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)"
Reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1"
Reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1"
Reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1"
Reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1"
Reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1"
Reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)"
Reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2"
Reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3"
Reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1"
Reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1"
Reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1"
Reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3"
Reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3"
Reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3"
Reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1"
Reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1"
Reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1"
Reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1"
Reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3"
Reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3"
Reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1"
Reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1"
Reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1"
Reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1"
Reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs"
Reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1"
Reactome:R-HSA-6790454 "SUMOylation of XPC"
Reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2"
Reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2"
Reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1"
Reactome:R-HSA-9920126 "UBC9 SUMOylates NS5"
Reactome:R-HSA-9926476 "UBE2I sumoylates MITF-M"
Reactome:R-HSA-9940458 "GATAD2B is SUMOylated"
Reactome:R-HSA-9940470 "GATAD2A is SUMOylated"