FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

translesion synthesis

ID (Ontology)

GO:0019985 (Gene Ontology)

Definition

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.[ PubMed:10535901 ]

Also Known As

"bypass DNA synthesis"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
translesion synthesis (all annotations which use CV term, excluding "NOT" statements)
involved_in \| translesion synthesis	--

Spanning Tree (Parents/Children)

DNA metabolic process
 |__DNA damage tolerance_______________________
DNA replication                                |
 |__DNA damage tolerance_______________________|
 |__DNA synthesis involved in DNA replication__|
DNA damage response                            |
 |__DNA damage tolerance_______________________|
DNA biosynthetic process                       |
 |__DNA synthesis involved in DNA replication__|
                                               translesion synthesis  10 rec.
                                                |__error-free translesion synthesis 2 rec.
                                                |__error-prone translesion synthesis 3 rec.
                                                    |__regulation of error-prone translesion synthesis(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA damage tolerance DNA synthesis involved in DNA replication
Part of
Synonyms & Secondary IDs
Synonyms
	"bypass DNA synthesis" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-73893 "DNA Damage Bypass"