FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term translesion synthesis ID (Ontology) GO:0019985 (Gene Ontology)
Definition The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.[ PubMed:10535901 ]
Also Known As "bypass DNA synthesis"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       6
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 Gene Groups Genes
 translesion synthesis (all annotations which use CV term, excluding "NOT" statements)       5      6
     involved_in | translesion synthesis       --       6
Spanning Tree (Parents/Children)
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DNA metabolic process
 |__DNA damage tolerance_______________________
DNA replication                                |
 |__DNA damage tolerance_______________________|
 |__DNA synthesis involved in DNA replication__|
DNA damage response                            |
 |__DNA damage tolerance_______________________|
DNA biosynthetic process                       |
 |__DNA synthesis involved in DNA replication__|
                                               translesion synthesis  13 rec.
                                                |__error-free translesion synthesis 2 rec.
                                                |__error-prone translesion synthesis 3 rec.
                                                    |__regulation of error-prone translesion synthesis(+)
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Is a DNA damage tolerance
DNA synthesis involved in DNA replication
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Synonyms
  • "bypass DNA synthesis" EXACT
Secondary IDs
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Reactome:R-HSA-73893 "DNA Damage Bypass"