FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term AP-2 adaptor complex ID (Ontology) GO:0030122 (Gene Ontology)
Definition A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).[ PubMed:10611976 PubMed:21097499 PubMed:22022230 PubMed:24322426 ]
Also Known As "HA2" ; "HA2 clathrin adaptor"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 AP-2 adaptor complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | AP-2 adaptor complex       --
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plasma membrane
 |__plasma membrane protein complex_________
clathrin-coated pit                         |
 |__clathrin coat of coated pit_____________|
clathrin coat                               |
 |__clathrin adaptor complex________________|
 |__clathrin coat of coated pit_____________|
AP-type membrane coat adaptor complex       |
 |__clathrin adaptor complex________________|
clathrin vesicle coat                       |
 |__clathrin coat of endocytic vesicle______|
clathrin-coated endocytic vesicle membrane  |
 |__clathrin coat of endocytic vesicle______|
membrane protein complex                    |
 |__plasma membrane protein complex_________|
plasma membrane protein complex             |
 |__clathrin coat of coated pit_____________|
                                            AP-2 adaptor complex  7 rec.
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Is a clathrin adaptor complex
plasma membrane protein complex
Part of clathrin coat of endocytic vesicle
clathrin coat of coated pit
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Synonyms
  • "HA2" EXACT
    "HA2 clathrin adaptor" EXACT
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