FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 5-formyltetrahydrofolate cyclo-ligase activity ID (Ontology) GO:0030272 (Gene Ontology)
Definition Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate.[ EC:6 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 5-formyltetrahydrofolate cyclo-ligase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | 5-formyltetrahydrofolate cyclo-ligase activity       1
Spanning Tree (Parents/Children)
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  ligase activity, forming carbon-nitrogen bonds
   |__cyclo-ligase activity
       |__5-formyltetrahydrofolate cyclo-ligase activity  1 rec.
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Is a cyclo-ligase activity
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Synonyms
  • "5,10-methenyltetrahydrofolate synthetase activity" RELATED[ EC:6 ]
    "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" RELATED[ EC:6 ]
    "5-formyltetrahydrofolate cyclodehydrase" BROAD[ EC:6 ]
    "5-Formyltetrahydrofolate cyclodehydrase activity" RELATED[ EC:6 ]
    "formyltetrahydrofolic cyclodehydrase activity" RELATED[ EC:6 ]
    "methenyl-THF synthetase activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.3.2
KEGG_REACTION:R02301
MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN
Reactome:R-HSA-6801342 "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG"
RHEA:10488