FB2026_03 , released September 17, 2026
CV Term Report
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Term DNA damage response, signal transduction by p53 class mediator ID (Ontology) GO:0030330 (Gene Ontology)
Definition A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 DNA damage response, signal transduction by p53 class mediator (all annotations which use CV term, excluding "NOT" statements)
     involved_in | DNA damage response, signal transduction by p53 class mediator
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DNA damage response
 |__signal transduction in response to DNA damage__
intracellular signal transduction                  |
 |__signal transduction in response to DNA damage__|
 |__signal transduction by p53 class mediator______|
                                                   DNA damage response, signal transduction by p53 class mediator  4 rec.
                                                    |__regulation of DNA damage response, signal transduction by p53 class mediator 2 rec.
                                                        |__negative regulation of DNA damage response, signal transduction by p53 class mediator 1 rec.
                                                        |__positive regulation of DNA damage response, signal transduction by p53 class mediator 1 rec.
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Is a signal transduction in response to DNA damage
signal transduction by p53 class mediator
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Synonyms
  • "DNA damage response, activation of p53" RELATED
    "p53 signaling pathway" RELATED
    "p53-mediated DNA damage response" BROAD
    "TP53 signaling pathway" RELATED
Secondary IDs
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Reactome:R-HSA-6791312 "TP53 Regulates Transcription of Cell Cycle Genes"
Reactome:R-HSA-69563 "p53-Dependent G1 DNA Damage Response"