FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term siRNA processing ID (Ontology) GO:0030422 (Gene Ontology)
Definition A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.[ PubMed:11524674 PubMed:19239886 PubMed:20687832 ]
Also Known As"chromatin silencing by small RNA, production of guide RNAs" ; "chromatin silencing by small RNA, production of siRNA" ; "production of guide RNAs involved in chromatin silencing by small RNA" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 Genes
 siRNA processing (all annotations which use CV term, excluding "NOT" statements)
     involved_in | siRNA processing
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RNA processing____________________________
regulatory ncRNA-mediated gene silencing__|
                                          regulatory ncRNA processing
                                           |__siRNA processing  13 rec.
                                               |__lsiRNA processing
                                               |__regulation of siRNA processing
                                               |   |__negative regulation of siRNA processing
                                               |   |__positive regulation of siRNA processing
                                               |__ta-siRNA processing
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Is a regulatory ncRNA processing
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Synonyms
  • "chromatin silencing by small RNA, production of guide RNAs" EXACT
    "chromatin silencing by small RNA, production of siRNA" EXACT
    "production of guide RNAs involved in chromatin silencing by small RNA" EXACT
    "production of guide RNAs involved in RNA interference" EXACT
    "production of siRNA" RELATED
    "production of siRNA involved in chromatin silencing by small RNA" EXACT
    "production of siRNA involved in gene silencing by small RNA" NARROW
    "production of siRNA involved in post-transcriptional gene silencing by RNA" EXACT
    "production of siRNA involved in PTGS" RELATED
    "production of siRNA involved in RNA interference" EXACT
    "RNA interference, production of guide RNAs" EXACT
    "RNA interference, production of siRNA" EXACT
Secondary IDs
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Reactome:R-HSA-426486 "Small interfering RNA (siRNA) biogenesis"