FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term [methionine synthase] reductase (NADPH) activity ID (Ontology) GO:0030586 (Gene Ontology)
Definition Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+.
Also Known As"[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 [methionine synthase] reductase (NADPH) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | [methionine synthase] reductase (NADPH) activity
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  oxidoreductase activity, acting on metal ions
   |__oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
       |__[methionine synthase] reductase (NADPH) activity  1 rec.
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Is a oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
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Synonyms
  • "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED
    "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT
    "methionine synthase cob(II)alamin reductase (methylating) activity" RELATED[ EC:1 ]
    "methionine synthase reductase activity" RELATED[ EC:1 ]
    "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" RELATED[ EC:1 ]
    "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.16.1.8
MetaCyc:2.1.1.135-RXN
Reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl"
RHEA:20752
RHEA:23908