FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term VCB complex ID (Ontology) GO:0030891 (Gene Ontology)
Definition A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.[ PubMed:11865071 ]
Also Known As"pVHL-elongin C-elongin B complex" ; "VHL complex" ; "von Hippel-Lindau tumor suppressor complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 VCB complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | VCB complex       --
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ubiquitin ligase complex__
cytoplasm_________________|
                          cytoplasmic ubiquitin ligase complex
                           |__VCB complex  3 rec.
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Is a cytoplasmic ubiquitin ligase complex
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Synonyms
  • "pVHL-elongin C-elongin B complex" EXACT
    "VHL complex" EXACT
    "von Hippel-Lindau tumor suppressor complex" EXACT
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