FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term endoplasmic reticulum unfolded protein response ID (Ontology) GO:0030968 (Gene Ontology)
Definition The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.[ PubMed:12042763 ]
Also Known As "ER unfolded protein response" ; "erUPR"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 endoplasmic reticulum unfolded protein response (all annotations which use CV term, excluding "NOT" statements)
     involved_in | endoplasmic reticulum unfolded protein response
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Vocabulary search 
response to unfolded protein
 |__cellular response to unfolded protein_____________
signal transduction                                   |
 |__intracellular signal transduction_________________|
cellular response to stress                           |
 |__response to endoplasmic reticulum stress__________|
cellular response to topologically incorrect protein  |
 |__cellular response to unfolded protein_____________|
                                                      endoplasmic reticulum unfolded protein response  25 rec.
                                                       |__ATF6-mediated unfolded protein response
                                                       |   |__regulation of ATF6-mediated unfolded protein response(+)
                                                       |__IRE1-mediated unfolded protein response 4 rec.
                                                       |   |__regulation of IRE1-mediated unfolded protein response(+) 2 rec.
                                                       |__PERK-mediated unfolded protein response 2 rec.
                                                       |   |__regulation of PERK-mediated unfolded protein response(+)
                                                       |__regulation of endoplasmic reticulum unfolded protein response 4 rec.
                                                           |__negative regulation of endoplasmic reticulum unfolded protein response(+) 2 rec.
                                                           |__positive regulation of endoplasmic reticulum unfolded protein response(+)
                                                           |__regulation of ATF6-mediated unfolded protein response(+)
                                                           |__regulation of IRE1-mediated unfolded protein response(+) 2 rec.
                                                           |__regulation of PERK-mediated unfolded protein response(+)
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Is a response to endoplasmic reticulum stress
intracellular signal transduction
Part of cellular response to unfolded protein
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Synonyms
  • "ER unfolded protein response" EXACT
    "erUPR" EXACT
    "SREBP-mediated signalling pathway" RELATED
Secondary IDs
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Reactome:R-HSA-381119 "Unfolded Protein Response (UPR)"