FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

anaphase-promoting complex-dependent catabolic process

ID (Ontology)

GO:0031145 (Gene Ontology)

Definition

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.[ PubMed:15380083 PubMed:15840442 ]

Also Known As

"anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" ; "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" ; "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
anaphase-promoting complex-dependent catabolic process (all annotations which use CV term, excluding "NOT" statements)
involved_in \| anaphase-promoting complex-dependent catabolic process	--

Spanning Tree (Parents/Children)

ubiquitin-dependent protein catabolic process__
proteasomal protein catabolic process__________|
                                               proteasome-mediated ubiquitin-dependent protein catabolic process
                                                |__anaphase-promoting complex-dependent catabolic process  19 rec.
                                                    |__regulation of anaphase-promoting complex-dependent catabolic process 4 rec.
                                                        |__negative regulation of anaphase-promoting complex-dependent catabolic process
                                                        |__positive regulation of anaphase-promoting complex-dependent catabolic process 4 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	proteasome-mediated ubiquitin-dependent protein catabolic process
Part of
Synonyms & Secondary IDs
Synonyms
	"anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT "cyclin breakdown" NARROW "cyclin catabolic process" NARROW "cyclin catabolism" NARROW "cyclin degradation" NARROW "degradation of cyclin" NARROW "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation" NARROW
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-174048 "APC/C:Cdc20 mediated degradation of Cyclin B" Reactome:R-HSA-174143 "APC/C-mediated degradation of cell cycle proteins" Reactome:R-HSA-174154 "APC/C:Cdc20 mediated degradation of Securin" Reactome:R-HSA-174184 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"