FB2026_03 , released September 17, 2026
CV Term Report
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Term DNA replication preinitiation complex ID (Ontology) GO:0031261 (Gene Ontology)
Definition A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.[ PubMed:12694535 PubMed:15194812 PubMed:17230184 ]
Also Known As"pre-IC"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 DNA replication preinitiation complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | DNA replication preinitiation complex
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nucleus
 |__nuclear protein-containing complex__
nuclear lumen                           |
 |__nucleoplasm_________________________|
protein-containing complex              |
 |__protein-DNA complex_________________|
 |__nuclear protein-containing complex__|
cellular anatomical structure           |
 |__nucleoplasm_________________________|
                                        DNA replication preinitiation complex  14 rec.
                                         |__CMG complex 12 rec.
                                         |__GINS complex 5 rec.
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Is a protein-DNA complex
nuclear protein-containing complex
Part of nucleoplasm
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