FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term peptidyl-proline dioxygenase activity ID (Ontology) GO:0031543 (Gene Ontology)
Definition Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.[ PubMed:24550447 PubMed:24550462 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 peptidyl-proline dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | peptidyl-proline dioxygenase activity       --
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catalytic activity
 |__catalytic activity, acting on a protein____________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
dioxygenase activity                                                                                   |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
                                                                                         peptidyl-proline dioxygenase activity  28 rec.
                                                                                          |__peptidyl-proline 3-dioxygenase activity
                                                                                          |   |__procollagen-proline 3-dioxygenase activity
                                                                                          |__peptidyl-proline 4-dioxygenase activity 26 rec.
                                                                                          |   |__hypoxia-inducible factor-proline dioxygenase activity 1 rec.
                                                                                          |   |__procollagen-proline 4-dioxygenase activity 25 rec.
                                                                                          |__procollagen-proline dioxygenase activity 25 rec.
                                                                                              |__procollagen-proline 3-dioxygenase activity
                                                                                              |__procollagen-proline 4-dioxygenase activity 25 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
catalytic activity, acting on a protein
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Synonyms
  • "proline hydroxylase activity" BROAD
    "proline,2-oxoglutarate 4-dioxygenase activity" BROAD
    "prolyl 4-hydroxylase activity" BROAD
    "prolyl hydroxylase activity" BROAD
Secondary IDs
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