FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term very long-chain fatty acid-CoA ligase activity ID (Ontology) GO:0031957 (Gene Ontology)
Definition Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.[ PubMed:18024425 ]
Also Known As"very-long-chain fatty acid-CoA ligase activity" ; "very-long-chain-fatty-acid-CoA ligase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 very long-chain fatty acid-CoA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | very long-chain fatty acid-CoA ligase activity
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fatty acid ligase activity__
CoA-ligase activity_________|
                            fatty acid-CoA ligase activity
                             |__very long-chain fatty acid-CoA ligase activity  2 rec.
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Is a fatty acid-CoA ligase activity
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Synonyms
  • "very-long-chain fatty acid activation" RELATED
    "very-long-chain fatty acid-CoA ligase activity" EXACT
    "very-long-chain-fatty-acid-CoA ligase activity" EXACT
Secondary IDs
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Reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA"
Reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA"
Reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA"
Reactome:R-HSA-9914143 "SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH"
RHEA:33639
RHEA:43748
RHEA:54536
RHEA:83103
RHEA:83107
RHEA:83111
RHEA:83403
RHEA:85311
RHEA:85315