FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

purine-rich negative regulatory element binding

ID (Ontology)

GO:0032422 (Gene Ontology)

Definition

Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.[ PubMed:9819411 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
purine-rich negative regulatory element binding (all annotations which use CV term, excluding "NOT" statements)
enables \| purine-rich negative regulatory element binding

Spanning Tree (Parents/Children)

transcription regulatory region nucleic acid binding__
sequence-specific double-stranded DNA binding_________|
                                                      transcription cis-regulatory region binding
                                                       |__purine-rich negative regulatory element binding  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	transcription cis-regulatory region binding
Part of
Synonyms & Secondary IDs
Synonyms
	"PNR element binding" BROAD
Secondary IDs

External Crossreferences & Linkouts