FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone demethylase activity ID (Ontology) GO:0032452 (Gene Ontology)
Definition Catalysis of the removal of a methyl group from a histone.
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 histone demethylase activity (all annotations which use CV term, excluding "NOT" statements)
      --
 NOT | enables | histone demethylase activity       --
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demethylase activity
 |__protein demethylase activity_________
catalytic activity, acting on a protein  |
 |__protein demethylase activity_________|
 |__histone modifying activity___________|
                                         histone demethylase activity  15 rec.
                                          |__histone H1 demethylase activity
                                          |__histone H3 demethylase activity 11 rec.
                                          |   |__histone H3K4 demethylase activity(+) 4 rec.
                                          |   |__histone H3K9 demethylase activity(+) 3 rec.
                                          |   |__histone H3K27me2/H3K27me3 demethylase activity 2 rec.
                                          |   |__histone H3K36 demethylase activity(+) 5 rec.
                                          |   |__histone H3K56me2/H3K56me3 demethylase activity 1 rec.
                                          |   |__histone H3R2 demethylase activity 1 rec.
                                          |__histone H4 demethylase activity 3 rec.
                                              |__histone H4K20 demethylase activity 1 rec.
                                              |__histone H4R3 demethylase activity 2 rec.
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Reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3"
Reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3"
Reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3"
Reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3"
Reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3"
Reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3"
Reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3"
Reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4"
Reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters"
Reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters"
Reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters"
Reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3"
Reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3"
Reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3"
Reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3"
Reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3"
Reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3"
Reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3"
Reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4"
Reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4"