FB2026_03 , released September 17, 2026

CV Term Report

Help Close All Open All

General Information

Term

calcineurin-NFAT signaling cascade

ID (Ontology)

GO:0033173 (Gene Ontology)

Definition

Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).[ PubMed:12975316 PubMed:15928679 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
calcineurin-NFAT signaling cascade (all annotations which use CV term, excluding "NOT" statements)
involved_in \| calcineurin-NFAT signaling cascade

Spanning Tree (Parents/Children)

  calcium-mediated signaling
   |__calcineurin-mediated signaling
       |__calcineurin-NFAT signaling cascade  7 rec.
           |__regulation of calcineurin-NFAT signaling cascade 6 rec.
               |__negative regulation of calcineurin-NFAT signaling cascade
               |__positive regulation of calcineurin-NFAT signaling cascade 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	calcineurin-mediated signaling
Part of
Synonyms & Secondary IDs
Synonyms
	"calcineurin-NFAT signaling pathway" RELATED "calcineurin-NFAT signalling pathway" RELATED
Secondary IDs

External Crossreferences & Linkouts