FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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Term proton-transporting V-type ATPase complex ID (Ontology) GO:0033176 (Gene Ontology)
Definition A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.[ ISBN:0716743663 PubMed:16449553 ]
Also Known As "hydrogen-translocating V-type ATPase complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 proton-transporting V-type ATPase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | proton-transporting V-type ATPase complex
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ATPase dependent transmembrane transport complex
 |__cation-transporting ATPase complex_____________
membrane protein complex                           |
 |__proton-transporting two-sector ATPase complex__|
catalytic complex                                  |
 |__ATPase complex_________________________________|
                                                   proton-transporting V-type ATPase complex  41 rec.
                                                    |__plasma membrane proton-transporting V-type ATPase complex 14 rec.
                                                    |   |__plasma membrane proton-transporting V-type ATPase, V0 domain
                                                    |   |__plasma membrane proton-transporting V-type ATPase, V1 domain
                                                    |__proton-transporting V-type ATPase, V0 domain 19 rec.
                                                    |   |__plasma membrane proton-transporting V-type ATPase, V0 domain
                                                    |   |__vacuolar proton-transporting V-type ATPase, V0 domain(+) 18 rec.
                                                    |__proton-transporting V-type ATPase, V1 domain 14 rec.
                                                    |   |__plasma membrane proton-transporting V-type ATPase, V1 domain
                                                    |   |__vacuolar proton-transporting V-type ATPase, V1 domain(+) 12 rec.
                                                    |__vacuolar proton-transporting V-type ATPase complex 35 rec.
                                                        |__lysosomal proton-transporting V-type ATPase complex(+)
                                                        |__vacuolar proton-transporting V-type ATPase, V0 domain(+) 18 rec.
                                                        |__vacuolar proton-transporting V-type ATPase, V1 domain(+) 12 rec.
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Is a proton-transporting two-sector ATPase complex
cation-transporting ATPase complex
ATPase complex
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Synonyms
  • "hydrogen-translocating V-type ATPase complex" EXACT
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