FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term sphingomyelin synthase activity ID (Ontology) GO:0033188 (Gene Ontology)
Definition Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin.[ EC:2 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 sphingomyelin synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | sphingomyelin synthase activity
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  transferase activity, transferring phosphorus-containing groups
   |__phosphotransferase activity, for other substituted phosphate groups
       |__sphingomyelin synthase activity  1 rec.
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Is a phosphotransferase activity, for other substituted phosphate groups
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Synonyms
  • "ceramide:phosphatidylcholine cholinephosphotransferase activity" RELATED[ EC:2 ]
    "phosphatidylcholine:ceramide cholinephosphotransferase activity" RELATED[ EC:2 ]
    "SM synthase activity" RELATED[ EC:2 ]
    "SMS1" RELATED[ EC:2 ]
    "SMS2" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.8.27
KEGG_REACTION:R08969
MetaCyc:2.7.8.27-RXN
Reactome:R-HSA-429786 "SGMS2 transfers phosphocholine onto ceramide"
Reactome:R-HSA-429798 "SGMS1 transfers phosphocholine onto ceramide"
RHEA:18765
RHEA:43320