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| Term | eukaryotic 48S preinitiation complex | ID (Ontology) | GO:0033290 (Gene Ontology) | |||||||
| Definition | The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.[ PubMed:16510876 PubMed:24319994 PubMed:24499181 PubMed:29735639 ] | |||||||||
| Also Known As | "eukaryotic 48S pre-initiation complex" | |||||||||
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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cytoplasm__________________ ribonucleoprotein complex__| cytosolic translation preinitiation complex |__eukaryotic 48S preinitiation complex 1 rec. |
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| Is a | cytosolic translation preinitiation complex | ||
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