FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term L-methionine cycle ID (Ontology) GO:0033353 (Gene Ontology)
Definition A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.[ PubMed:31950558 PubMed:32961717 PubMed:39394448 ]
Also Known As "activated methyl cycle" ; "S-adenosylmethionine cycle" ; "SAM cycle"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
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 L-methionine cycle (all annotations which use CV term, excluding "NOT" statements)
     involved_in | L-methionine cycle       --
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sulfur amino acid metabolic process
 |__L-methionine metabolic process______________
 |__homocysteine metabolic process______________|
sulfur compound metabolic process               |
 |__S-adenosylmethionine metabolic process______|
metabolic process                               |
 |__modified amino acid metabolic process_______|
ribonucleoside metabolic process                |
 |__purine ribonucleoside metabolic process_____|
purine nucleoside metabolic process             |
 |__purine ribonucleoside metabolic process_____|
small molecule metabolic process                |
 |__one-carbon metabolic process________________|
proteinogenic amino acid metabolic process      |
 |__L-methionine metabolic process______________|
non-proteinogenic amino acid metabolic process  |
 |__homocysteine metabolic process______________|
                                                L-methionine cycle  15 rec.
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Is a L-methionine metabolic process
modified amino acid metabolic process
one-carbon metabolic process
purine ribonucleoside metabolic process
S-adenosylmethionine metabolic process
homocysteine metabolic process
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Synonyms
  • "activated methyl cycle" EXACT
    "S-adenosylmethionine cycle" EXACT
    "SAM cycle" EXACT
Secondary IDs
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MetaCyc:PWY-5041
MetyaCyc:PWY-6151