FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term L-methionine cycle ID (Ontology) GO:0033353 (Gene Ontology)
Definition A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.[ PubMed:31950558 PubMed:39394448 ]
Also Known As "activated methyl cycle" ; "S-adenosylmethionine cycle" ; "SAM cycle"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      12
Genes (FBgn)  GO_CELLULAR_COMPONENT       4
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 L-methionine cycle (all annotations which use CV term, excluding "NOT" statements)       1     13
     involved_in | L-methionine cycle       --      12
Spanning Tree (Parents/Children)
Only view relationship: 
sulfur amino acid metabolic process
 |__L-methionine metabolic process______________
 |__homocysteine metabolic process______________|
sulfur compound metabolic process               |
 |__S-adenosylmethionine metabolic process______|
metabolic process                               |
 |__modified amino acid metabolic process_______|
ribonucleoside metabolic process                |
 |__purine ribonucleoside metabolic process_____|
purine nucleoside metabolic process             |
 |__purine ribonucleoside metabolic process_____|
L-amino acid metabolic process                  |
 |__L-methionine metabolic process______________|
proteinogenic amino acid metabolic process      |
 |__L-methionine metabolic process______________|
non-proteinogenic amino acid metabolic process  |
 |__homocysteine metabolic process______________|
alpha-amino acid metabolic process              |
 |__homocysteine metabolic process______________|
                                                L-methionine cycle  14 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a L-methionine metabolic process
modified amino acid metabolic process
purine ribonucleoside metabolic process
S-adenosylmethionine metabolic process
homocysteine metabolic process
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "activated methyl cycle" EXACT
    "S-adenosylmethionine cycle" EXACT
    "SAM cycle" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
MetaCyc:PWY-5041
MetyaCyc:PWY-6151