FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ribonuclease T2 activity ID (Ontology) GO:0033897 (Gene Ontology)
Definition Catalysis of the reaction: a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H+. This reaction is a two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.[ EC:4 ]
Also Known As"acid ribonuclease activity" ; "acid RNase activity" ; "base-non-specific ribonuclease activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ribonuclease T2 activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ribonuclease T2 activity
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endonuclease activity
 |__RNA endonuclease activity_________
RNA nuclease activity                 |
 |__RNA endonuclease activity_________|
lyase activity                        |
 |__phosphorus-oxygen lyase activity__|
                                      ribonuclease T2 activity  2 rec.
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Is a RNA endonuclease activity
phosphorus-oxygen lyase activity
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Synonyms
  • "acid ribonuclease activity" EXACT
    "acid RNase activity" EXACT
    "base-non-specific ribonuclease activity" EXACT
    "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT
    "Escherichia coli ribonuclease II activity" RELATED[ EC:4 ]
    "non-base specific ribonuclease activity" EXACT
    "nonbase-specific RNase activity" EXACT
    "nonspecific RNase activity" EXACT
    "ribonnuclease (non-base specific) activity" EXACT
    "ribonuclease (non-base specific) activity" RELATED
    "ribonuclease II activity" BROAD[ EC:4 ]
    "ribonuclease M activity" EXACT
    "ribonuclease N2 activity" EXACT
    "ribonuclease PP3 activity" RELATED
    "ribonuclease U4 activity" EXACT
    "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT
    "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD
    "RNAase CL activity" EXACT
    "RNase (non-base specific) activity" EXACT
    "RNase II activity" BROAD[ EC:4 ]
    "RNase M activity" RELATED
    "RNase Ms activity" EXACT
    "RNase T2 activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.6.1.19
MetaCyc:3.1.27.5-RXN
RHEA:68052