FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity ID (Ontology) GO:0033925 (Gene Ontology)
Definition Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
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  hydrolase activity, acting on glycosyl bonds
   |__hydrolase activity, hydrolyzing O-glycosyl compounds
       |__mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity  1 rec.
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Is a hydrolase activity, hydrolyzing O-glycosyl compounds
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Synonyms
  • "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" RELATED[ EC:3 ]
    "endo-beta-(1->4)-N-acetylglucosaminidase activity" RELATED[ EC:3 ]
    "endo-beta-acetylglucosaminidase activity" RELATED[ EC:3 ]
    "endo-beta-N-acetylglucosaminidase activity" RELATED[ EC:3 ]
    "endo-beta-N-acetylglucosaminidase D activity" RELATED[ EC:3 ]
    "endo-beta-N-acetylglucosaminidase F activity" RELATED[ EC:3 ]
    "endo-beta-N-acetylglucosaminidase H activity" RELATED[ EC:3 ]
    "endo-beta-N-acetylglucosaminidase L activity" RELATED[ EC:3 ]
    "endo-N-acetyl-beta-D-glucosaminidase activity" RELATED[ EC:3 ]
    "endo-N-acetyl-beta-glucosaminidase activity" RELATED[ EC:3 ]
    "endoglycosidase H activity" RELATED[ EC:3 ]
    "endoglycosidase S activity" RELATED[ EC:3 ]
    "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" RELATED[ EC:3 ]
    "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" RELATED[ EC:3 ]
    "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" RELATED[ EC:3 ]
    "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" RELATED[ EC:3 ]
    "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.2.1.96
MetaCyc:3.2.1.96-RXN
Reactome:R-HSA-8853379 "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)"