FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term deoxyhypusine synthase activity ID (Ontology) GO:0034038 (Gene Ontology)
Definition Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 deoxyhypusine synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | deoxyhypusine synthase activity
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  transferase activity
   |__transferase activity, transferring alkyl or aryl (other than methyl) groups
       |__deoxyhypusine synthase activity  1 rec.
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Is a transferase activity, transferring alkyl or aryl (other than methyl) groups
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Synonyms
  • "(4-aminobutyl)lysine synthase" BROAD[ EC:2 ]
    "eIF-5A-deoxyhypusine synthase activity" RELATED[ EC:2 ]
    "spermidine dehydrogenase" BROAD[ EC:2 ]
Secondary IDs
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EC:2.5.1.46
MetaCyc:2.5.1.46-RXN
Reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A"
Reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine"
RHEA:33299