FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

VCP-NPL4-UFD1 AAA ATPase complex

ID (Ontology)

GO:0034098 (Gene Ontology)

Definition

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).[ PubMed:11813000 PubMed:16179952 ]

Also Known As

"p97-Ufd1-Npl4 complex"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
VCP-NPL4-UFD1 AAA ATPase complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| VCP-NPL4-UFD1 AAA ATPase complex

Spanning Tree (Parents/Children)

endoplasmic reticulum
 |__endoplasmic reticulum protein-containing complex___________
membrane                                                       |
 |__membrane protein complex___________________________________|
organelle membrane                                             |
 |__endoplasmic reticulum membrane_____________________________|
protein-containing complex                                     |
 |__membrane protein complex___________________________________|
 |__endoplasmic reticulum protein-containing complex___________|
nuclear outer membrane-endoplasmic reticulum membrane network  |
 |__endoplasmic reticulum membrane_____________________________|
endoplasmic reticulum subcompartment                           |
 |__endoplasmic reticulum membrane_____________________________|
                                                               VCP-NPL4-UFD1 AAA ATPase complex  4 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	membrane protein complex endoplasmic reticulum protein-containing complex
Part of	endoplasmic reticulum membrane
Synonyms & Secondary IDs
Synonyms
	"Cdc48p-Npl4p-Ufd1p AAA ATPase complex" NARROW "p97-Ufd1-Npl4 complex" EXACT[ PubMed:12847084 ]
Secondary IDs

External Crossreferences & Linkouts