FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term toll-like receptor 4 signaling pathway ID (Ontology) GO:0034142 (Gene Ontology)
Definition The series of molecular signals initiated by a ligand binding to toll-like receptor 4.[ PubMed:16551253 PubMed:17328678 ]
Also Known As"TLR4 signaling pathway" ; "toll-like receptor 4 signalling pathway"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 toll-like receptor 4 signaling pathway (all annotations which use CV term, excluding "NOT" statements)
     involved_in | toll-like receptor 4 signaling pathway
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  cell surface pattern recognition receptor signaling pathway
   |__cell surface toll-like receptor signaling pathway
       |__toll-like receptor 4 signaling pathway  2 rec.
           |__MyD88-dependent toll-like receptor 4 signaling pathway
           |__regulation of toll-like receptor 4 signaling pathway
           |   |__negative regulation of toll-like receptor 4 signaling pathway
           |   |__positive regulation of toll-like receptor 4 signaling pathway
           |__TIRAP-dependent toll-like receptor 4 signaling pathway
           |__TRAM-dependent toll-like receptor 4 signaling pathway
           |__TRIF-dependent toll-like receptor 4 signaling pathway
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Is a cell surface toll-like receptor signaling pathway
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Synonyms
  • "TLR4 signaling pathway" EXACT
    "toll-like receptor 4 signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-166016 "Toll Like Receptor 4 (TLR4) Cascade"