FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

'de novo' NAD+ biosynthetic process from L-tryptophan

ID (Ontology)

GO:0034354 (Gene Ontology)

Definition

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), beginning with the catabolism of L-tryptophan into the precursor quinolinate. NAD+ is a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions.[ PubMed:17161604 ]

Also Known As

"'de novo' NAD biosynthetic process from L-tryptophan"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
'de novo' NAD+ biosynthetic process from L-tryptophan (all annotations which use CV term, excluding "NOT" statements)
involved_in \| 'de novo' NAD+ biosynthetic process from L-tryptophan

Spanning Tree (Parents/Children)

purine nucleotide biosynthetic process
 |__NAD+ biosynthetic process_____________________
amino acid metabolic process                      |
 |__aromatic amino acid metabolic process_________|
 |__proteinogenic amino acid metabolic process____|
metabolic process                                 |
 |__indole-containing compound metabolic process__|
nicotinamide nucleotide biosynthetic process      |
 |__NAD+ biosynthetic process_____________________|
NAD+ metabolic process                            |
 |__NAD+ biosynthetic process_____________________|
carboxylic acid metabolic process                 |
 |__aromatic amino acid metabolic process_________|
 |__proteinogenic amino acid metabolic process____|
                                                  'de novo' NAD+ biosynthetic process from L-tryptophan  1 rec.
                                                   |__regulation of 'de novo' NAD biosynthetic process from L-tryptophan
                                                       |__negative regulation of 'de novo' NAD biosynthetic process from L-tryptophan
                                                       |__positive regulation of 'de novo' NAD biosynthetic process from L-tryptophan

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	aromatic amino acid metabolic process NAD+ biosynthetic process indole-containing compound metabolic process proteinogenic amino acid metabolic process
Part of
Synonyms & Secondary IDs
Synonyms
	"'de novo' NAD biosynthetic process from L-tryptophan" EXACT "'de novo' NAD biosynthetic process from tryptophan" BROAD "de novo NAD biosynthetic process from tryptophan" RELATED "kynurenine pathway" BROAD
Secondary IDs

External Crossreferences & Linkouts
	MetaCyc:NADSYN-PWY MetaCyc:PWY-5653