FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term ubiquitin-ubiquitin ligase activity ID (Ontology) GO:0034450 (Gene Ontology)
Definition Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.[ PubMed:10089879 PubMed:17190603 ]
Also Known As "E4"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       5
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 ubiquitin-ubiquitin ligase activity (all annotations which use CV term, excluding "NOT" statements)       5
     enables | ubiquitin-ubiquitin ligase activity       5
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ubiquitin-protein transferase activity__
ubiquitin-like protein ligase activity__|
                                        ubiquitin protein ligase activity
                                         |__ubiquitin-ubiquitin ligase activity  5 rec.
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Is a ubiquitin protein ligase activity
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Synonyms
  • "E4" EXACT
Secondary IDs
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Reactome:R-HSA-937050 "Pellino ubiquitinates hp-IRAK1"
Reactome:R-HSA-975122 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
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