FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ID (Ontology) GO:0034597 (Gene Ontology)
Definition Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Also Known As"1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" ; "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
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phosphatidylinositol bisphosphate phosphatase activity
 |__phosphatidylinositol-4,5-bisphosphate phosphatase activity__
phosphatidylinositol phosphate phosphatase activity             |
 |__phosphatidylinositol phosphate 4-phosphatase activity_______|
                                                                phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  1 rec.
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Is a phosphatidylinositol phosphate 4-phosphatase activity
phosphatidylinositol-4,5-bisphosphate phosphatase activity
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Synonyms
  • "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT
    "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT
Secondary IDs
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EC:3.1.3.78
Reactome:R-HSA-6810410 "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus"
RHEA:25674