FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone H3K4me/H3K4me2/H3K4me3 demethylase activity ID (Ontology) GO:0034647 (Gene Ontology)
Definition Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.[ PubMed:17550896 PubMed:22473470 ]
Also Known As"histone demethylase activity (H3-K4-me3 specific)" ; "histone demethylase activity (H3-trimethyl-K4 specific)" ; "histone H3-tri/di/monomethyl-lysine-4 demethylase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 histone H3K4me/H3K4me2/H3K4me3 demethylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H3K4me/H3K4me2/H3K4me3 demethylase activity
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
 |__2-oxoglutarate-dependent dioxygenase activity__
dioxygenase activity                               |
 |__2-oxoglutarate-dependent dioxygenase activity__|
histone H3 demethylase activity                    |
 |__histone H3K4 demethylase activity______________|
                                                   histone H3K4me/H3K4me2/H3K4me3 demethylase activity  3 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
histone H3K4 demethylase activity
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Synonyms
  • "H3K4me3 demethylase activity" RELATED
    "histone demethylase activity (H3-K4-me3 specific)" EXACT
    "histone demethylase activity (H3-trimethyl-K4 specific)" EXACT
    "histone H3-K4me2 demethylase activity" BROAD
    "histone H3-K4me3 demethylase activity" RELATED
    "histone H3-tri/di/monomethyl-lysine-4 demethylase activity" EXACT
    "histone H3K4me2 demethylase activity" BROAD
Secondary IDs
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EC:1.14.11.67
RHEA:60208